| Miami FC vs. Detroit City FC | 3-8-2025
Saturday
TBD | Pitbull Stadium in Miami, FL | View Tickets |
| Detroit City FC vs. Birmingham Legion FC | 3-22-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
| Louisville City FC vs. Detroit City FC | 3-29-2025
Saturday
TBD | Lynn Family Stadium in Louisville, KY | View Tickets |
| Phoenix Rising FC vs. Detroit City FC | 4-12-2025
Saturday
TBD | Phoenix Rising FC Stadium in Phoenix, AZ | View Tickets |
| Indy Eleven vs. Detroit City FC | 5-3-2025
Saturday
TBD | Carroll Stadium in Indianapolis, IN | View Tickets |
| Birmingham Legion FC vs. Detroit City FC | 5-18-2025
Sunday
TBD | Protective Stadium in Birmingham, AL | View Tickets |
| Detroit City FC vs. Charleston Battery | 5-24-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
| Loudoun United FC vs. Detroit City FC | 6-14-2025
Saturday
TBD | Segra Field in Leesburg, VA | View Tickets |
| Detroit City FC vs. Miami FC | 6-21-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
| Hartford Athletic FC vs. Detroit City FC | 6-28-2025
Saturday
TBD | Trinity Health Stadium in Hartford, CT | View Tickets |
| Detroit City FC vs. Hartford Athletic FC | 7-12-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
| Rhode Island FC vs. Detroit City FC | 8-6-2025
Wednesday
TBD | Tidewater Landing Stadium in Pawtucket, RI | View Tickets |
| Detroit City FC vs. Tampa Bay Rowdies | 8-23-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
| Detroit City FC vs. San Antonio FC | 8-30-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
| Detroit City FC vs. Orange County SC | 9-6-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
| New Mexico United vs. Detroit City FC | 9-10-2025
Wednesday
TBD | Rio Grande Credit Union Field at Isotopes Park in Albuquerque, NM | View Tickets |
| Detroit City FC vs. Lexington Sporting Club | 9-20-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
| Detroit City FC vs. North Carolina FC | 10-4-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
| Detroit City FC vs. Loudoun United FC | 10-11-2025
Saturday
TBD | Keyworth Stadium in Hamtramck, MI | View Tickets |
